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チカ母 抱っこが大好きな娘のおかげで腕だけやたらとたくましいお母さん。
Professor Catherine Orrell MBChB MMed MSc (Clin Pharmacol) PhD (Cape Town)
Clinical Lead for the DTHF Centre for Adherence and Therapeutics (D-CAT); Pharmacokinetic Study Leader at the Groote Schuur Hospital Clinical Research Site, Department of Medicine, Faculty of Health Sciences.
Catherine 如何在中应用和使用Gator振荡器 Olymp Trade Orrell is a clinical pharmacologist and clinical trials specialist who has worked as principal and co-investigator in clinical research at the DTHF since 1998. She has been principal investigator on 20 clinical trials and sub-investigator on more than 30 trials of antiretroviral drugs, including a range of efficacy, toxicity, interaction and dosing studies. She has in-depth experience conducting research in both state-of-the-art research facilities at UCT, including the Groote Schuur CRS, which is a HPTN and HVTN-affiliated site, and the DTHF Clinical Trials Unit, as well as in primary healthcare clinic environments, where she leads a DAIDS-approved non-networked research site in Gugulethu, the DTHF Centre for Adherence and Therapeutics (D-CAT) within the Gugulethu community.
Catherine is an experienced HIV clinician who played an integral role in developing 如何在中应用和使用Gator振荡器 Olymp Trade a number of HIV care and treatment services in the Cape Town area. Over the past 20 years of work in the antiretroviral field, she has developed a deep interest in factors promoting the success of antiretroviral therapy when delivered in a resource-poor setting to large numbers of people, including adherence, retention in care and task-shifting to other staff cadres.
The research at D-CAT focuses on novel methods to monitor and improve adherence to HIV and TB medication in a resource-poor setting, including through the use of electronic pillboxes and therapeutic drug monitoring. Here they use scalable interventions including text messaging, differentiated care, lay counselor-based motivational interviewing, and peer education to improve adherence and retention in typical South African ART (antiretroviral therapy) clinics; and it is at the confluence of novel approaches to therapeutics and medication adherence that the core of her research work at DCAT is focused.
Key areas of expertise: Adherence to ART, retention in HIV care and ART drug pharmacology and resistance.
Current research projects:
- Viiv/Johnson and Johnson (PI: Orrell) 01 Oct 2022 - 30 Sep 2025
Use of long-acting injectable ART among Adolescent and Young Adults in South Africa (AFINaty) - EDCTP (TMA2019 SFP-2812 (PI: Orrell) 01 Nov 2021 - 31 Dec 2025 Improving RETention and viral load outcomes for people taking Antiretroviral therapy through early IdentificatioN of missed doses.
- NIH/R011MH125703-01A1 (PI: Orrell, Sabin) 01 Jul 2021 – 30 Jun 2026
SUpporting Sustained HIV Treatment Adherence after Initiation - NIH/R01AI152119 (PI: Van Zyl, Orrell, Gandhi) 07 Jul 2020 – 30 Jun 2023
Urine tenofovir point-of-care test to identify patients in need of ART adherence support (UTRA study) - NIH/R01AI122300 (PI: Orrell, Remien) 01 Dec 2015 – 30 Nov 2022
Use of ARV Drug Levels in DBS to Assess and Manage ART Adherence in South Africa (ADD-ART)
Selected publications:
See publications and profile on Research Gate.
Contact details:
The Desmond Tutu HIV Centre
Institute of Infectious Disease and Molecular Medicine
University of Cape Town
Associate Professor Darren Martin PhD (Cape Town)
Division of Computational Biology, Department of Integrative Biomedical Sciences, & Member of the Institute of Infectious 如何在中应用和使用Gator振荡器 Olymp Trade Disease and Molecular Medicine(IDM), Faculty of Health Sciences, University of Cape Town
The Computational Biology (CBIO) Group is the centre of 如何在中应用和使用Gator振荡器 Olymp Trade Bioinformatics activities at the University. It aims to perform world-class bioinformatics research and provide high-quality bioinformatics education, training, and services. The CBIO Division is part of the Department of Integrative Biomedical Sciences and is located within the IDM. Darren Martin’s main research interests 如何在中应用和使用Gator振荡器 Olymp Trade lie in studying the role that genetic recombination plays during 如何在中应用和使用Gator振荡器 Olymp Trade virus evolution.
As a mechanism that generates virus sequence diversity, recombination participates in the evolution of enhanced pathogenicity, drug resistance, and vaccine escape. Using computational recombination-analysis tools developed at the IDM, his group are searching for recombination hot- and cold-spots within the genomes of all currently described virus families. With a focus on combining computational and wet-lab experimental approaches Darren’s group tests hypothesis relating to genetic recombination, the evolution of genome-scale secondary structures and fitness trad-offs. For example, the group has shown that obligatory maintenance of the delicate network of co-evolved intra-genomic interactions that define the biology of virus species, severely limits the types of recombination events that are tolerable in nature. By demarcating the sub-genome modules that are and are not tolerably exchanged between viruses, recombination hot and cold spot maps should be applicable to the rational design of "recombination resistant" vaccines and drugs against viruses such as HIV and Hepatitis C. Such maps should also be applicable to the identification of genome regions that interact with one another.
Selected publications:
RDP4: Detection and analysis of recombination patterns in virus genomes. DP Martin, B Murrell, M Golden, A Khoosal, B Muhire. Virus Evolution 1 (1), vev003.
Pervasive tertiary structure in the 如何在中应用和使用Gator振荡器 Olymp Trade dengue virus RNA genome. Dethoff EA, Boerneke MA, Gokhale NS, 如何在中应用和使用Gator振荡器 Olymp Trade Muhire BM, Martin DP, Sacco MT, McFadden MJ, Weinstein JB, Messer WB, Horner SM, Weeks KM. Proc Natl Acad Sci U S A. 2018 115(45):11513-11518.
Integrative landscape of dysregulated signaling pathways of clinically distinct pancreatic cancer subtypes. Sinkala M, Mulder N, Martin DP. 2018. Oncotarget 26;9(49):29123. (JIF 5,如何在中应用和使用Gator振荡器 Olymp Trade 168).
SDT: a virus classification tool based on pairwise sequence alignment and identity calculation. Muhire BM, Varsani A, Martin DP. PLoS 如何在中应用和使用Gator振荡器 Olymp Trade One. 2014 Sep 26;9(9):e108277. doi: 10.1371/journal.pone.0108277.
Patterns of genomic site inheritance in HIV-1M inter-subtype recombinants delineate the most likely genomic sites of subtype-specific adaptation. Tongo M, de Oliveira T, Martin DP. Virus Evolution 2018 11;4(1):vey015.
Contact details:
Division of Computational Biology
Room N1.05 Werner Beit North Building
Institute of Infectious Disease and Molecular Medicine
UCT Faculty of Health Sciences
Anzio Road, Observatory 7925
South Africa